Dr. rer. nat. Przemyslaw Bozko



  • Winiarska K., Bozko P., Lietz T., Bryla J. Importance of glutamate dehydrogenase stimulation for glucose and glutamine synthesis in rabbit renal tubules incubated with various amino acids. Acta Biochimica Polonica. 1998.
  • Bozko P., Larsen AK., Raymond E., Skladanowski A. Influence of G2 arrest on the cytotoxicity of topoisomerase inhibitors toward human carcinoma cells with different p53 status. Acta Biochimica Polonica. 2002.
  • Issaeva, N., , Friedler, A., Bozko, P. Wiman K.G., Fersht, A.R., Selivanova, G. Rescue and upregulation of p53 in cells by Fl-CDB3. PNAS. 2003.
  • Issaeva N., Bozko P., Enge M., Protopopova M., Verhoef L., Masucci M., Pramanik A., Selivanova G., Small molecule RITA binds to p53, blocks p53/HDM-2 interaction and activates p53 function in tumor cells in vitro and in vivo”. Nat Med. 2004.
  • Hyzy M., Bozko P., Konopa J., Skladanowski A. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005.
  • Bozko P., Sabisz M., Larsen AK., Skladanowski A. Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacological implications. Molecular Cancer Therapeutics. 2005.
  • Rasheva V., Knight D., Bozko P., Marsh K., Frolov MV. Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila. Molecular and Cellular Biology. 2006.
  • Schweitzer K., Bozko P., Dubiel W., Naumann M. CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. EMBO 2007.
  • Skladanowski A., Bozko P., Sabisz M.,Larsen AK. Dual Inhibition of PI3K/Akt Signaling and the DNA Damage Checkpoint in p53-Deficient Cells with Strong Survival Signaling: Implications for Cancer Therapy. Cell Cycle. 2007.
  • Bozko P., Larsen AK., Skladanowski A. The influence of G2 arrest abrogation on the long-term cytotoxicity of different genotoxic lesions. Cell Cycle. 2008.
  • Sokolova O., Bozko P., Naumann M. Helicobacter pylori suppresses GSK3beta to promote beta-catenin activity. J. Biol. Chem. 2008.
  • Skladanowski A., Bozko P., Sabisz M. DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment. Chemical Reviews. 2009.
  • Schweitzer K., Sokolova O., Bozko P., Naumann M. Helicobacter pylori induces NF-κB independent of CagA. EMBO Rep. 2010.
  • Podhorecka M., Skladanowski A., Bozko P. H2AX phosphorylation, its role in DNA damage response and cancer therapy. Journal of Nucleic Acids. 2010.
  • Bien J., Sokolova O., Bozko P. Characterization of Virulence Factors of Staphylococcus aureus: Novel Function of Known Virulence Factors That Are Implicated in Activation of Airway Epithelial Proinflammatory Response. J Pathog. 2011.
    Bien J., Sokolova O., Bozko P. Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage. Int J Nephrol. 2012.
  • Podhorecka M., Bozko P. Editorial: The importance of rational chemotherapy of chronic lymphocytic leukemia. Curr Pharm Des. 2012.
  • Palagani V., El Khatib M., Kossatz U., Bozko P., Müller M., Manns M., Krech T., Malek N., Plentz R. Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by -secretase inhibitor IX. PLOS ONE, 2012.
  • Bien J., Palagani V., Bozko P. The intestinal microbiota dysbiosis and Clostridium difficile infection – is there relationship with inflammatory bowel disease? Therapeutic Advances in Gastroenterology. 2013.
  • Zender S., Nickeleit I., Wuestefeld T., Sörensen I., Dauch D., Bozko P., El-Khatib M., Geffers R., Bektas H., Manns MP., Gossler A., Wilkens L., Plentz R., Zender L., Malek NP. A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell. 2013.
  • El Khatib M., Bozko P., Palagani V., Malek NP., Wilkens L., Plentz RR. Activation of Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo. PLoS One. 2013.
  • Palagani V., Bozko P., El Khatib M., Belahmer H., Giese N., Sipos B., Malek NP., Plentz RR. Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression. Carcinogenesis. 2014.
  • Niggemann J., Bozko P., Bruns N., Wodtke A., Gieseler MT., Thomas K., Jahns C., Nimtz M., Reupke I., Brüser T., Auling G., Malek NP., Kalesse M. Baceridin, a Cyclic Hexapeptide from an Epiphytic Bacillus Strain, Inhibits the Proteasome. Chembiochem. 2014.
  • Wutka A., Palagani V., Barat S., Chen X., El Khatib M., Götze J., Belahmer H., Zender S., Bozko P., Malek NP., Plentz RR. Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. PLoS One. 2014.
  • Bien J., Bozko M., Malek NP., Bozko P. Editorial: Helicobacter pylori Eradication Therapy: Advantages and Disadvantages Curr Pharm Des. 2014.
  • Bien J., Bozko M., Malek NP., Bozko P. Editorial: Gut Microbiota and Gastrointestinal Diseases: To Treat or Not to Treat. Curr Pharm Des. 2014.
  • Sokolova O., Vieth M., Gnad T., Bozko P., Naumann M. Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR.Int J Biochem Cell Biol. 2014.
  • Barat S., Bozko P., Chen X., Scholta T., Hanert F., Götze J., Malek NP., Wilkens L., Plentz RR. Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma. Mol Carcinog. 2016.
  • Müller A., Barat S., Chen X., Bui KC., Bozko P., Malek NP, Plentz RR. Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines. Int J Oncol. 2016.
  • Podhorecka M., Macheta A., Bozko M., Bozko A., Malek NP., Bozko P. Deregulation of apoptosis – is it still an important issue in pathogenesis of chronic lymphocytic leukemia? Curr Cancer Drug Targets. 2016.
  • Bozko M., Podhorecka M., Macheta A., Bozko A., Malek NP., Bozko P. Editorial: Pathogenetic Mechanisms of CLL – A Target in Therapy. Curr Cancer Drug Targets. 2016.
  • Dauch D., Rudalska R., Cossa G., Nault JC., Kang TW., Wuestefeld T., Hohmeyer A., Imbeaud S., Yevsa T., Hoenicke L., Pantsar T., Bozko P., Malek NP., Longerich T., Laufer S., Poso A., Zucman-Rossi J., Eilers M., Zender L. A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. Nat Med. 2016.
  • Barat S., Chen X., Cuong Bui K., Bozko P., Götze J., Christgen M., Krech T., Malek NP., Plentz RR. Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and wnt-beta-catenin Pathways in CD44+ Gastric Cancer Stem Cells. Stem Cells Transl Med. 2017.
  • Chen X., Bui KC., Barat S., Thi Nguyen ML., Bozko P., Sipos B., Kalesse M., Malek NP., Plentz RR. Therapeutic effects of Argyrin F in pancreatic adenocarcinoma. Cancer Lett. 2017.